| # | Swimmer | Team | Seed | Time | Diff |
| 1 |
Eliason, Sarah K (12)
|
PVRMSC |
4:51.14 |
4:47.62 |
-3.52 |
| 2 |
Qin, Amy W (12)
|
PVRMSC |
4:54.50 |
4:47.78 |
-6.72 |
| 3 |
Kuang, Gloria J (11)
|
PVDRAG |
4:55.40 |
4:54.01 |
-1.39 |
| 4 |
Madison, Kendall E (12)
|
MDCAA |
4:58.55 |
4:57.73 |
-0.82 |
| 5 |
Lee, Elena G (12)
|
MDEST |
5:17.63 |
5:14.66 |
-2.97 |
| 6 |
Romberger, Brielle N (12)
|
MDGBSA |
5:29.20 |
5:19.52 |
-9.68 |
| 7 |
Freund, Gabrielle J (12)
|
MDCAA |
5:09.47 |
5:21.48 |
12.01 |
| 8 |
O'Brien, Makenzie M (12)
|
MDEST |
5:21.28 |
5:23.97 |
2.69 |
| 9 |
Sanders, Katherine G (11)
|
MDGBSA |
5:36.69 |
5:24.05 |
-12.64 |
| 10 |
Firth, Kaitlyn L (12)
|
MDRAC |
5:38.94 |
5:25.18 |
-13.76 |
|
Hawkins, Jillian E (12)
|
MDEST |
5:15.51 |
DQ |
- |
|
Starr, Amelia J (11)
|
MDGBSA |
5:22.51 |
DQ |
- |
|
Emrich, Taylor N (12)
|
MDRAC |
5:06.32 |
DQ |
- |